The city lies on the National Route Number 7 that connects Mendoza (255 km) with Buenos Aires (791 km), parallel to the Río Chorrillos River. The other closest provincial capitals are San Juan (323 km) and Córdoba (412 km).
Interesting point of the city are the Park of the Nations, the neoclassical cathedral, a number of museums including the Dora Ochoa De Masramón Provincial Museum, and the colonial architecture. Fishing in the nearby locations is also popular. The Sierra de las Quijadas National Park is located 122 kilometres from the city.
The city's climate is continental with temperatures around 3ºC and 33ºC, an annual average of 17ºC.
The San Luis Airport (IATA: LUQ, ICAO: SAQU) at coordinates 33°16′38″S, 66°21′09″W is only a few hundred meters from the centre, has regular flight to Buenos Aires.
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